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With the seal unbroken, closet or room could escape the fires and acids of disinfection procedures if plague subsequently entered the the black plague in the elizibethan era household. The overall impact of plague on the national death rate, however, diminished progressively. HistoryThe earliest known visitation of the plague to Europe may have occurred in Athens in 430. Topley and Wilson microbiology and microbiological infections, vol. Garrett, global health expert, won numerous awards as medical and science writer for Newsday.